冯华芳¹，蒋 伟^3#，舒邦金¹，兰 余¹，蔺 霖¹，曹晓念^1，2*

（1.泸州老窖股份有限公司，泸州646000；2.国家固态酿造工程技术研究中心，泸州646000；

3.华中农业大学生物医学与健康学院，武汉430070）

摘要：该文以荔枝干、枸杞子、玫瑰花、绿豆等原料酿制而成的养生酒为研究对象，重点评估饮用养生酒对机体的作用效应和对神经系统的影响。该文首先采用小鼠神经元细胞（HT22），将细胞分为三个实验组：空白对照组、基酒组和养生酒组，分别处理24h后，评估细胞活力及氧化损伤指标的变化；随后以小鼠为研究对象，将小鼠随机分配为三个实验组：空白对照组、基酒组和养生酒组，连续28d进行灌胃处理，监测小鼠血液中乙醇和维生素B1的含量变化，并检测小鼠脑组织中的氧化损伤、炎症因子、神经营养相关因子及神经递质水平的变化。研究结果表明，与基酒组相比，养生酒组极显著提升了小鼠血液中维生素B1含量，加速了乙醇的代谢；同时，养生酒组显著提高了HT22细胞和小鼠脑组织中的超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的活性；此外，养生酒组还极显著降低了小鼠脑组织中的C反应蛋白（CRP）水平，并极显著提升了白介素10（IL-10）水平；显著降低了小鼠脑组织中的神经生长因子（NGF）、碱性成纤维细胞生长因子（bFGF）和乙酰胆碱（Ach）水平。综上所述，该养生酒不仅具有一定的抗氧化和抗炎特性，还展现出对神经系统损伤的缓解作用。

关键词：养生酒；乙醇代谢速率；神经系统保护；抗氧化；抗炎

中图分类号：TS262.91 文献标识码：A 文章编号：1674-506X（2025）03-0053-0007

Study on the Post-consumption Effects of Health Liquor Based on Murine Organism Effects

FENG Huafang¹, JIANG Wei^3#, SHU Bangjin¹, LAN Yu¹, LIN Lin¹, CAO Xiaonian^{1, 2*}

(1.Luzhou Laojiao Co., Ltd., Luzhou 646000, China;

2.National Engineering Research Center of Solid-state Brewing, Luzhou 646000, China;

3.College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China)

Abstract: This paper used health liquor brewed from ingredients such as dried lychee, wolfberry, rose, and mung bean as research object, focused on evaluating the physiological effects of drinking health liquor and impacts on nervous system. The paper first utilized （HT22） mouse neuronal cells, which were divided into three experimental groups： blank control group, base liquor group, and health liquor group. After 24 h treatments, changes in cell viability and oxidative damage indicators were assessed; Subsequently,  mice were used as research objects,  mice were randomly assigned to three experimental groups： blank control group, base liquor group, and health liquor group, with consecutive 28 d oral gavage. The changes in ethanol and vitamin B1 contents in the blood of mice were monitored, and the changes in oxidative damage, inflammatory factors, neurotrophic- related factors, and neurotransmitter levels in the brain tissue of mice were detected. Research results demonstrated that compared to the base liquor group, the health liquor group significantly increased vitamin B1 contents in mice blood and accelerated ethanol metabolism; In the meantime, health liquor group markedly enhanced superoxide dismutase （SOD） and catalase （CAT） activities in both HT22 cells and mouse brain tissue. Furthermore, the health liquor group significantly reduced C-reactive protein （CRP） level in mouse brain tissue while significantly increasing interleukin- 10 （IL- 10） level; it notably decreased levels of nerve growth factor （NGF）,basic fibroblast growth factor （bFGF）,and acetylcholine （Ach） in mouse brain tissue. In conclusion, the health liquor not only exhibits antioxidative and anti-inflammatory properties while demonstrating alleviating effects on neurological damage.

Keywords: health liquor; ethanol metabolic rate; nervous system protection; antioxidation; anti-inflammation 

doi: 10.3969/j.issn.1674-506X.2025.03-008